D-myo-Inositol-1,4,6-triphosphate (sodium salt)
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CAT No. CS-AU-00018
Category Phosphoinositols
CAS 157380-18-2
Mol. Weight 486 g/mol
Mol. Formula C6H12O15P3.3Na
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Product Description
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Synonyms sodium (1R,2R,3S,4R,5S,6R)-3,5,6-trihydroxycyclohexane-1,2,4-triyl tris(hydrogenphosphate)
Purity (%) >98%
Application Notes D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals.1,2 The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5 Ins(1,4,6)-P3 (tested as the meso compound) is 9-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.6
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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NIST Calibrated