Anastrozole EP Impurity E

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CAT No.# CS-CB-00029
Category Impurities
CAS 120511-88-8
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Molecular Weight 242.32
Molecular Formula C15H18N2O
Synonyms: 2,2'-(5-(hydroxymethyl)-1,3-phenylene)bis(2-methylpropanenitrile); 1,3-Benzenediacetonitrile, 5-(hydroxymethyl)-a1,a1,a3,a3-tetramethyl; 2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
Application Notes: 2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile (Anastrozole EP Impurity E ) is an impurity of Anastrozole (A637425), an aromatase inhibitor which functions as an antineoplastic (1,2). Anastrozole is used in post-menopausal women with advanced breast cancer.
References: 1. Plourde, P. et al.: Breast Cancer Res Treat. 1994;30(1):103-11 2. Buzdar, A. et al.: Cancer. 1997 Feb 15;79(4):730-9.
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