Borrelidin
METABOLITES    
Availability: Available - Dispatch by : 21-Dec-2019 5:00 PM
CAT No. CS-CM-00038
Category Metabolites
Parent API Borrelidin
CAS 7184-60-3
Mol. Weight 489.64 g/mol
Mol. Formula C28H43NO6
View COA View MSDS
Product Description
Stock Status Available - Dispatch by : 21-Dec-2019 5:00 PM
Synonyms 2-((4E,6E)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
Application Notes Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Originally discovered as active against Borrelia species, borrelidin has since found a role as a selective inhibitor of bacterial and eukaryal threonyltRNA synthetase. More recent research has found that borrelidin is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases.
Pubchem Id 6436801
Smiles CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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Related Results

- API Standards of Borrelidin
- Stable Isotopes of Borrelidin
- Metabolites of Borrelidin
- Impurities of Borrelidin
- Glucuronides of Borrelidin
- Intermediates of Borrelidin

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c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated


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