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CAT No. CS-CM-00046
Category Metabolites
Parent API Curvularin
CAS 10140-70-2
Mol. Weight 292.32 g/mol
Mol. Formula C16H20O5
View COA View MSDS
Product Description
Stock Status Compound under re-stock / certification. Please enquire for exact delivery date
Synonyms (S)-11,13-dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-1H-benzo[d][1]oxacyclododecine-2,10-dione
Application Notes Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.Studies in relation to biosynthesis. Part XX. The structure and biosynthesis of curvularin.
Pubchem Id 119418
Smiles CC1CCCCCC(=O)C2=C(CC(=O)O1)C=C(C=C2O)O
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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Related Results

- API Standards of Curvularin
- Stable Isotopes of Curvularin
- Metabolites of Curvularin
- Impurities of Curvularin
- Glucuronides of Curvularin
- Intermediates of Curvularin

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