Monactin
METABOLITES    
Availability: Dispatch by : 5-Nov-2019 5:00 PM
CAT No. CS-CM-00127
Category Metabolites
Parent API Monactin
CAS 7182-54-9
Mol. Weight 750.95 mol/g
Mol. Formula C41H66O12
Product Description
Stock Status Dispatch by : 5-Nov-2019 5:00 PM
Synonyms (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-5-ethyl-2,11,14,20,23,29,32-heptamethyl-
4,13,22,31,37,38,39,40-
octaoxapentacyclo[32.2.1.17,¹°.1¹6,¹.1²5,²8]tetracontane-
3,12,21,30-tetrone
Application Notes Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN.Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation.
COA / MSDS View COA   MSDS
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

c1
ISO 9001:2005
c2
ISO Guide 34:2009
c3
ISO/IEC 17025:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated
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