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CAT No. CS-CM-00152
Category Metabolites
Parent API Pyridomycin
CAS 18791-21-4
Mol. Weight 540.56 g/mol
Mol. Formula C27H32N4O8
View COA View MSDS
Product Description
Stock Status Compound under re-stock / certification. Please enquire for exact delivery date
Synonyms N-((5R,6S,9S,10R,11R,Z)-2-(butan-2-ylidene)-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-(pyridin-3-ylmethyl)-1,4-dioxa-8-azacyclododecan-6-yl)-3-hydroxypicolinamide
Application Notes pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under several names. The unusual 12-membered macrocyclic depsipeptide comprises three unique sub-units incorporating two substituted pyridines. Pyridomycin is thought to target NADH-dependent enoyl (acyl-carrier-protein) reductase InhA. Recent reports of activity against isoniazid-resistant mycobacteria has seen pyridomycin identified as a potential lead for new generation antibiotics.A new antibiotic, pyridomycin.
References Shirude Pravin S., Madhavapeddi Prashanti, Naik Maruti, Murugan Kannan, Shinde Vikas, Nandishaiah Radha, Bhat Jyothi, Kumar Anupriya, Hameed Shahul, Holdgate Geoffrey, Davies Gareth, McMiken Helen, Hegde Naina, Ambady Anisha, Venkatraman Janani, Panda Man
Pubchem Id 3037036
Smiles CCC(=C1C(=O)OC(C(C(=O)NC(C(C(C(=O)O1)C)O)CC2=CN=CC=C2)NC(=O)C3=C(C=CC=N3)O)C)C
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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Related Results

- API Standards of Pyridomycin
- Stable Isotopes of Pyridomycin
- Metabolites of Pyridomycin
- Impurities of Pyridomycin
- Glucuronides of Pyridomycin
- Intermediates of Pyridomycin

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