1-(2'-Chloro-2'-deoxy-β-D-arabinofuranosyl)cytosine

FINE CHEMICALS

Product Details

CAT No.# CS-N-00141
Category Fine Chemicals
CAS 58461-30-6
Molecular Weight 261.662
Molecular Formula C9H12ClN3O4
Purity: >98%
Synonyms: 58461-30-6;AC1O57SO;1-(2-Chloro-2-deoxy-D-arabinofuranosyl)cytosine;2(1H)-Pyrimidinone, 4-amino-1-(2-chloro-2-deoxy-beta-D-arabinofuranosyl)-;4-Amino-1-(2-chloro-2-deoxy-.beta.-D-arabinofuranosyl)pyrimidin-2(1H)-one;4-amino-1-[(2R,3S,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Application Notes: Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase- a (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). 1 It induces apoptosis in primary chronic lymphocytic
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  1. Fine Chemicals
  2. 1-(2'-Chloro-2'-deoxy-β-D-arabinofuranosyl)cytosine

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