Dolutegravir
API STANDARDS    
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Dispatch by : 23-Nov-2019 5:00 PM
CAT No. CS-O-00218
Category API Standards
Parent API Dolutegravir
CAS 1051375-16-6
Mol. Weight 419.37 mol/g
Mol. Formula C20H19F2N3O5
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Product Description
Stock Status In-Stock
Dispatch by : 23-Nov-2019 5:00 PM
Synonyms (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine49572;
Storage Conditions
Purity (%) 99.53
Melting Point (℃)188-190 
Solubility DMSO
Appearance White to Pale Yellow Solid
Application Notes Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peri
References Kobayashi, M. et al. Antimcrob Agentschemother., 55, 813 (2011); Garrido,c. et al.: Antiviral, Res., 90, 164 (2011); Lenz, Jcc. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);
Pubchem Id 54726191
Smileys CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
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The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated
Related Results

- API Standards of Dolutegravir
- Stable Isotopes of Dolutegravir
- Metabolites of Dolutegravir
- Impurities of Dolutegravir
- Glucuronides of Dolutegravir
- Intermediates of Dolutegravir

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