Eplerenone
API STANDARDS    
Availability: In-Stock
Dispatch by : 15-Nov-2019 5:00 PM
CAT No. CS-O-01427
Category API Standards
Parent API Eplerenone
CAS 107724-20-9
Mol. Weight 414.49 mol/g
Mol. Formula C24H30O6
Product Description
Stock Status In-Stock
Dispatch by : 15-Nov-2019 5:00 PM
Synonyms pregn-4-ene-7,21droxy-3-oxo, γter (7a, 11a, 17a); Eplerenone; Epoxymexrenone; Inspra; Selara;
Storage Conditions
Purity (%) >98%
Appearance Powder
Application Notes Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
References Struthers A, Krum H, Williams GH (2008; Delyani, John A (2000)
Smileys C[C@@](C(C[C@H]1C(O[13C]([2H])([2H])[2H])=O)=CC2=O)(CC2)[C@]34[C@]1([H])[C@@](CC[C@@]5(O6)CCC6=O)([H])[C@]5(C)C[C@H]3O4
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The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated
Related Results

- API Standards of Eplerenone
- Stable Isotopes of Eplerenone
- Metabolites of Eplerenone
- Impurities of Eplerenone
- Glucuronides of Eplerenone
- Intermediates of Eplerenone

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