Smiles
O=C1C=C(C[C@@]2([H])C(OC)=O)[C@@](CC1)(C)[C@]34[C@]2([H])[C@@](CC[C@@]5(O6)CCC6=O)([H])[C@]5(C)C[C@@]3([H])O4
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-methyl
4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[
cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
References
"De Gasparo et al (1987) Three new epoxy-spirolctone derivatives:charcterization in vivo and in vitro, J,Pharmcol,Exp,Ther, 240 650, cMahon (2001) Rcent studies with eplerenone; a novel selctive aldosterone rceptor antagonist,curr,Opin,Pharmcol, 1 190,"
Application Notes
"Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors."
Purity by HPLC
Not less than 95%
Hazard Compound
Refer MSDS for complete information.
