Eplerenone
API STANDARDS    
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Dispatch to US by: 26-May-2020 5:00 PM

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CAT No. CS-O-01427
Category API Standards
Parent API Eplerenone
CAS 107724-20-9
Mol. Weight 414.49 g/mol
Mol. Formula C24H30O6
View COA View MSDS
Product Description
Stock Status In-Stock
Dispatch to US by: 26-May-2020 5:00 PM
Synonyms Not Available
Storage Conditions Store at refrigerator (2-8C) for long term storage
Purity (%) Not less than 95%
Stability NULL
Solubility Soluble in DMSO
Appearance White to off white solid
Application Notes "Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors."
References "De Gasparo et al (1987) Three new epoxy-spirolctone derivatives:charcterization in vivo and in vitro, J,Pharmcol,Exp,Ther, 240 650, cMahon (2001) Rcent studies with eplerenone; a novel selctive aldosterone rceptor antagonist,curr,Opin,Pharmcol, 1 190,"
Smiles C[C@@](C(C[C@H]1C(O[13C]([2H])([2H])[2H])=O)=CC2=O)(CC2)[C@]34[C@]1([H])[C@@](CC[C@@]5(O6)CCC6=O)([H])[C@]5(C)C[C@H]3O4
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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Related Results

- API Standards of Eplerenone
- Stable Isotopes of Eplerenone
- Metabolites of Eplerenone
- Impurities of Eplerenone
- Glucuronides of Eplerenone
- Intermediates of Eplerenone


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