Retigabine
API STANDARDS    
Availability: In-Stock
Dispatch by : 13-Nov-2019 5:00 PM
CAT No. CS-O-02282
Category API Standards
Parent API Retigabine
CAS 150812-12-7
Mol. Weight 303.33 mol/g
Mol. Formula C16H18FN3O2
Product Description
Stock Status In-Stock
Dispatch by : 13-Nov-2019 5:00 PM
Synonyms N-(2-Amino-4-(4-fluorobenzylamino)phenylcarbamc cid Ethyl Ester;Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenylcarbamate; D23129; Ezogabine; GKE 841; GW 582892X; Potiga; Trobalt; WAY 143841
Storage Conditions
Purity (%) >98%
Appearance Light Blue Solid
Application Notes Retigabine is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive
References Dailey, J.W.; et al.: Neurociece Lett., 195, 77 (1995),chanvitayapongs, S., et al. 1997. Neuroreport. 8: 1499-1502. Gehm, B.D., et al. 1997. Prc. Natl. cad. ci. U.S.A. 94: 14138-14143. Fontcave, M., et al. 1998. FEBS Lett. 421: 277-279. Srivastava, P., et al. 1998. Int. J. Ocol. 13: 465-469. ;chun, Y.J., et al. 1999. Bichem. Biophys. Res.commun. 262: 20-24. Bowers, J.L., et al. 2000. Endcrinology. 141: 3657-3667. Frémont, L., 2000. Life ci. 66: 663-673. Kimura, Y., 2003. Methods Find Expclin Pharmcol. 25: 297-310. Howitz, K.T., et al. 2003. Nature. 425: 191-196. Baur, J.A. and Siclair, D.A. 2006. Nat Rev Drug Dicov. 5: 493-506. PMID: 16732220 Lei, M., et al. 2008. cta Pharmcol. Sin. 29: 1350-1356. Pandey, P.R., et al. 2010. Breastcacer Res Treat. Gurusamy, N., et al. 2010. J.cell. Mol. Med. 14: 2235-2239. Kao,c.L., et al. 2010. Stemcells Dev. 19: 247-258.
Smileys O=C(OCC)NC(C=CC(NCC1=CC=C(F)C=C1)=C2)=C2N
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The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

c1
ISO 9001:2005
c2
ISO Guide 34:2009
c3
ISO/IEC 17025:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated
Related Results

- API Standards of Retigabine
- Stable Isotopes of Retigabine
- Metabolites of Retigabine
- Impurities of Retigabine
- Glucuronides of Retigabine
- Intermediates of Retigabine

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