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CAT No. CS-O-02282
Category API Standards
Parent API Retigabine
CAS 150812-12-7
Mol. Weight 303.33 g/mol
Mol. Formula C16H18FN3O2
View COA View MSDS
Product Description
Stock Status In-Stock
Dispatch to US by: 2-Jun-2020 5:00 PM
Synonyms N-(2-Amino-4-(4-fluorobenzylamino)phenylcarbamc cid Ethyl Ester;Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenylcarbamate; D23129; Ezogabine; GKE 841; GW 582892X; Potiga; Trobalt; WAY 143841
Storage Conditions Store at refrigerator (2-8°C) for long term storage
Purity (%) Not less than 95%
Stability NULL
Solubility Soluble in DMSO
Appearance Light brown solid
Application Notes Retigabine is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive
References "Dailey; J,W,; et al,: Neurociece Lett,; 195; 77 (1995);chanvitayapongs; S,; et al, 1997, Neuroreport, 8: 1499-1502, Gehm; B,D,; et al, 1997, Prc, Natl, cad, ci, U,S,A, 94: 14138-14143, Fontcave; M,; et al, 1998, FEBS Lett, 421: 277-279, Srivastava; P,; et al, 1998, Int, J, Ocol, 13: 465-469, ;chun; Y,J,; et al, 1999, Bichem, Biophys, Res,commun, 262: 20-24, Bowers; J,L,; et al, 2000, Endcrinology, 141: 3657-3667, Frémont; L,; 2000, Life ci, 66: 663-673, Kimura; Y,; 2003, Methods Find Expclin Pharmcol, 25: 297-310, Howitz; K,T,; et al, 2003, Nature, 425: 191-196, Baur; J,A, and Siclair; D,A, 2006, Nat Rev Drug Dicov, 5: 493-506, PMID: 16732220 Lei; M,; et al, 2008, cta Pharmcol, Sin, 29: 1350-1356, Pandey; P,R,; et al, 2010, Breastcacer Res Treat, Gurusamy; N,; et al, 2010, J,cell, Mol, Med, 14: 2235-2239, Kao;c,L,; et al, 2010, Stemcells Dev, 19: 247-258,"
Smiles O=C(OCC)NC(C=CC(NCC1=CC=C(F)C=C1)=C2)=C2N
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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Related Results

- API Standards of Retigabine
- Stable Isotopes of Retigabine
- Metabolites of Retigabine
- Impurities of Retigabine
- Glucuronides of Retigabine
- Intermediates of Retigabine

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