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For Research Purposes only. Not for Personal use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
54-85-3
Product Code
CS-O-10901
M.F.
C₆H₇N₃O
M.W.
137.14
Smiles
O=C(C1=CC=NC=C1)NN
Category
Reference Standard
API Family
Isoniazid
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
4-Pyridinecarboxylic Acid Hydrazide
References
"Brewer; G,A,; et al,: Anal, Profiles Drug Subs,; 6; 183 (1977); Weber; W,W,; et al,: Clin, Pharmacokinet,; 4; 401 (1979)"
Synonyms
Not available,
Application Notes
"Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic)."
Purity by HPLC
Not less than 95%
Hazard Compound
Refer MSDS for accurate information.
Overview
"Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic)."
