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(1S,2R) Bortezomib

Chiral Standards
CAT No.
:
CS-O-20087

CAS No.

:

1132709-16-0

Molecular Weight

:

384.24

Molecular Formula

:

C19H25BN4O4

Purity

:

99.47 %

Long Term Storage

:

2-8°C

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:

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Product Application Notes

(1S,3R)-Bortezomib is an diastereomer of Bortezomib , the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus



Smileys

O=C(N[C@H](B(O)O)CC(C)C)[C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2



Synonyms

(1S,2R) Bortezomib;[(1S)-3-methyl-1-[(2R)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronc Acid



References

Nawrcki, S.T., et al:cacer Reseach, 65, 11510 (2005); Drahlc.:chem. and Eng. News, 87, 41 (2009)



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