Smiles
O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone
References
"Asano, K,, et al,: In Vivo, 10, 537 (1996), McCall, E,, et al,: Circ, Res,, 79, 1110 (1996), Raufman, J,P,, et al,: J, Biol, Chem,, 271, 19877 (1996), Rokaw, M,D,, et al,: Am, J, Physiol,, 271, C194 (1996), Knoll, G,A,, and Bell, R,C,: Brit, Med, J,, 318,|???|???????"
Synonyms
Prograph;
Protopic;
Protopy;
TacroBell;
Tacrolimus
Application Notes
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for accurate information.
