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Docetaxel - Impurity E

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Product Code: CS-O-31076 Reference Standard
Docetaxel - Impurity E
API Family
Baccatin
Product Code
CS-O-31076

Docetaxel - Impurity E

Baccatin Reference Standard
Stock Status: In Stock
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CAT No.
CS-O-31076
CAS No.
32981-86-5
Molecular Formula
C₂₉H₃₆O₁₀
Molecular Weight
544.59
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
32981-86-5
Product Code
CS-O-31076
M.F.
C₂₉H₃₆O₁₀
M.W.
544.59
Category
Reference Standard
API Family
Baccatin
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11- tetrahydroxy4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12bdodecahydro-1H7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
References
"Lataste, H,,Senilh, V,,Wright, M,, et al; Proc, Natl, Acad, Sci, USA 81(13), 4090-4094 (1984),"
Synonyms
-
Application Notes
"Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3"
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for accurate information.
Overview
"Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3"

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