Selexipag acyl β-D-Glucuronide
GLUCURONIDES    
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CAT No. CS-O-32678
Category Glucuronides
Parent API Selexipag
CAS NA
Mol. Weight 595.64 g/mol
Mol. Formula C31H37N3O9
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Product Description
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Synonyms MRE-269 β-D-Glucuronide; 2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2- yl)amino]butoxy}acetic acid β-D-Glucuronide
Purity (%) >98
Application Notes MRE-269 β-D-Glucuronide can be obtained from 4-Amino-1-butanol which is used in the synthesis of NSAIDs with anti-inflammatory properties.4-Amino-1-butanol is also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells. MRE-269 β-D-Glucuronide is Glucuronide metabolite of Selexipag. The drug is first hydrolyzed to an active metabolite, ACT 33679 (CAS#475085-57-5, planned) in the liver and then glucuronidated afterwards.
References Majumder, J. et al.: Langmuir, 29, 10254 (2013); Muth, A. et al.: J. Med. Chem., 56, 5819 (2013)
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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Related Results

- API Standards of Selexipag
- Stable Isotopes of Selexipag
- Metabolites of Selexipag
- Impurities of Selexipag
- Glucuronides of Selexipag
- Intermediates of Selexipag


Quality Assurance


c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c4
ISO 17034:2016
c5
ISO/IEC 17025:2017
c5
NIST Calibrated