Selexipag acyl β-D-Glucuronide

GLUCURONIDES

Product Details

CAT No.# CS-O-32678
Category Glucuronides
CAS NA
Molecular Weight 595.64
Molecular Formula C31H37N3O9
Purity: >98
Synonyms: MRE-269 β-D-Glucuronide; 2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2- yl)amino]butoxy}acetic acid β-D-Glucuronide
Application Notes: MRE-269 β-D-Glucuronide can be obtained from 4-Amino-1-butanol which is used in the synthesis of NSAIDs with anti-inflammatory properties.4-Amino-1-butanol is also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells. MRE-269 β-D-Glucuronide is Glucuronide metabolite of Selexipag. The drug is first hydrolyzed to an active metabolite, ACT 33679 (CAS#475085-57-5, planned) in the liver and then glucuronidated afterwards.
References: Majumder, J. et al.: Langmuir, 29, 10254 (2013); Muth, A. et al.: J. Med. Chem., 56, 5819 (2013)
COA / MSDS:    View COA    MSDS    Enquire
The balance used are calibrated with weights traceable to National Standards NIST for accuracy
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