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MRE-269 β-D-Glucuronide can be obtained from 4-Amino-1-butanol which is used in the synthesis of NSAIDs with anti-inflammatory properties.4-Amino-1-butanol is also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells. MRE-269 β-D-Glucuronide is Glucuronide metabolite of Selexipag. The drug is first hydrolyzed to an active metabolite, ACT 33679 (CAS#475085-57-5, planned) in the liver and then glucuronidated afterwards.
Majumder, J. et al.: Langmuir, 29, 10254 (2013); Muth, A. et al.: J. Med. Chem., 56, 5819 (2013)
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy
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