Indomethacin Ethyl Ester

IMPURITIES

Product Details

CAT No.# CS-P-08096
Category Impurities
CAS 16401-99-3
Molecular Weight 385.85
Molecular Formula C21H20ClNO4
Purity: >98
Synonyms: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-Indole-3-acetic Acid Ethyl Ester; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid Ethyl Ester; Ethyl 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate; Ethyl 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetate; Indomethacin EP Impurity I
Application Notes: Indomethacin Ethyl Ester (Indomethacin EP Impurity I) is the ethyl ester of the nonsteroidal anti-inflammatory drug Indomethacin (I641000). Indomethacin Ethyl Ester is a selective COX-2 inhibitor and is used (along with Indomethacin) as loaded nanocapsules as anticancer treatment showing a decrease in glioma cell proliferation.
References: Kalgutkar, A.S., et al.: J. Med. Chem., 43, 2860 (2000); Bernardi, A., et al.: Eur. J. Pharmacol., 586, 24 (2008);
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