Dorsomorphin Dihydrochloride
API STANDARDS    
Availability: Available - Dispatch by : 25-Dec-2019 5:00 PM
CAT No. CS-T-21334
Category API Standards
Parent API Dorsomorphin
CAS 1219168-18-9
Mol. Weight 472.41 g/mol
Mol. Formula C24H27Cl2N5O
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Product Description
Stock Status Available - Dispatch by : 25-Dec-2019 5:00 PM
Synonyms 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride
Purity (%) >98%
Application Notes Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
References Shen, Q.W., Gerrard, D.E., Du, M.: Meat Sci., 78, 323 (2008); Yu, P., et. al.: Nat. Chem. Biol., 4, 33 (2008); Kim, H., et. al.: J. Biol. Chem., 283, 3731 (2008)
Smiles C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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Related Results

- API Standards of Dorsomorphin
- Stable Isotopes of Dorsomorphin
- Metabolites of Dorsomorphin
- Impurities of Dorsomorphin
- Glucuronides of Dorsomorphin
- Intermediates of Dorsomorphin

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c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated


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