Dorsomorphin Dihydrochloride


Product Details

CAT No.# CS-T-21334
Category API Standards
CAS 1219168-18-9
Molecular Weight 472.41
Molecular Formula C24H27Cl2N5O
Purity: >98%
Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride
Application Notes: Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
References: Shen, Q.W., Gerrard, D.E., Du, M.: Meat Sci., 78, 323 (2008); Yu, P., et. al.: Nat. Chem. Biol., 4, 33 (2008); Kim, H., et. al.: J. Biol. Chem., 283, 3731 (2008)
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The balance used are calibrated with weights traceable to National Standards NIST for accuracy
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This page contains information about Dorsomorphin Dihydrochloride Cas 1219168-18-9 and its API Standards.
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