Dorsomorphin Dihydrochloride

API STANDARDS

Product Details

CAT No.# CS-T-21334
Category API Standards
CAS 1219168-18-9
Molecular Weight 472.41
Molecular Formula C24H27Cl2N5O
Purity: >98%
Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride
Application Notes: Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
References: Shen, Q.W., Gerrard, D.E., Du, M.: Meat Sci., 78, 323 (2008); Yu, P., et. al.: Nat. Chem. Biol., 4, 33 (2008); Kim, H., et. al.: J. Biol. Chem., 283, 3731 (2008)
COA / MSDS:    View COA    MSDS    Enquire
The balance used are calibrated with weights traceable to National Standards NIST for accuracy
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7. Icatibant impurity 1
8. BISPHENOL AF (RING-13C12)
9. 0.1% TFA in Water ULC-MS
10. Metamizole EP Impurity C HCl
11. Silodosin Metabolite D4
12. Brivaracetam Carboxylic acid metabolite [UCB 42145]
13. Terbuthylazine D5
14. tibolone (848)
15. (Z)-Dimethylvinphos
16. Silodosin Metabolite
17. 2-Phenoxymethanesulfonanilide
18. Nimesulide EP Impurity A
19. Acetone HPLC
20. Nandrolone Decanoate EP impurity F


SMILES:
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl



This page contains information about Dorsomorphin Dihydrochloride Cas 1219168-18-9 and its API Standards.
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