Availability: Available - Dispatch by : 27-Nov-2019 5:00 PM
CAT No. CS-T-29711
Category API Standards
Parent API Demecolcine
CAS 4702-33-4
Mol. Weight 371.43 mol/g
Mol. Formula C21H25NO5
Product Description
Stock Status Available - Dispatch by : 27-Nov-2019 5:00 PM
Synonyms (S)-6,7-Dihydro-1,2,3,9-tetramethoxy-7-(methylamino)-benzo[a]heptalen-10(5H)-one
Purity (%) >98%
Solubility Chloroform, Dichlormethane, DMSO, Ethanol, Ethyl Acetate, Methanol
Appearance Yellow Solid
Application Notes An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev
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The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

ISO 9001:2005
ISO Guide 34:2009
ISO/IEC 17025:2005
OHSAS 18001:2007
ISO 14001:2005
NIST Calibrated
Related Results

- API Standards of Demecolcine
- Stable Isotopes of Demecolcine
- Metabolites of Demecolcine
- Impurities of Demecolcine
- Glucuronides of Demecolcine
- Intermediates of Demecolcine

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