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CAT No. CS-T-42003
Category Inhibitors
CAS 141807-57-0
Mol. Weight 392.32 g/mol
Mol. Formula C21H23Cl2NO2
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Product Description
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Synonyms (1R,2S,3S,5S)-3-lo[3.2.ic Acid Phenyl Ester Hydrochloride;phenyl 3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride
Purity (%) >98%
Application Notes RTI-113 is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.
References Dworkin, S. et al.: Synapse, 30, 49 (1998); Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009); Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002);
Pubchem Id 9886800
Smiles CN1C2CCC1C(C(C2)C3=CC=C(C=C3)Cl)C(=O)OC4=CC=CC=C4.Cl
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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