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CAT No. CS-T-42034
Category Inhibitors
CAS 215303-72-3
Mol. Weight 425.51 g/mol
Mol. Formula C27H24FN3O
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Product Description
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Synonyms 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol;4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol
Purity (%) >98%
Application Notes RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. Studies show that RWJ-67657 might provide a useful tool to intervene in the deranged immune response in sepsis and other inflammatory diseases. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells,
References Fijen, J. et al.: Clin. Exp. Immunol., 124, 16 (2001); Westra, J. et al.: Int. Immunopharmacol., 5, 1259 (2005); Westra, J. et al.: Ann. Rheum. Dis., 63, 1453 (2004);
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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