Tyrphostin AG 879
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CAT No. CS-T-46067
Category Inhibitors
CAS 148741-30-4
Mol. Weight 316.46 g/mol
Mol. Formula C18H24N2OS
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Product Description
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Synonyms (2E)- 3-[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]hioamide;(E)-3-amino-2-((3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl)-3-mercaptoacrylonitrile
Purity (%) >98%
Application Notes Tyrphostin is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy and was shown to sensitize prostate cancer cells to apoptosis.
References Chen. L., et al.: Clin. Cancer.Res., 17, 6218 (2011); Tohtouh, T., et al.: J. Med. Chem., 55, 9312 (2012);
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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NIST Calibrated