URB754
INHIBITORS    
Availability: Available - Dispatch to by : 30-Dec-2019 5:00 PM
CAT No. CS-T-46149
Category Inhibitors
CAS 86672-58-4
Mol. Weight 266.3 g/mol
Mol. Formula C16H14N2O2
View COA View MSDS
Product Description
Stock Status Available - Dispatch to by : 30-Dec-2019 5:00 PM
Synonyms 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one;6-methyl-2-(p-tolylamino)-4H-benzo[d][1,3]oxazin-4-one
Purity (%) >98%
Melting Point (℃)201-203 
Solubility DMSO
Appearance Off-White Solid
Application Notes URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 M and binds weakly to the rat CB1 receptor with an IC50 of 3.8 M. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 M. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
References Makara, J.K., et al.: Nat. Neurosci., 8, 1139 (2005)
Smiles O=C1OC(NC2=CC=C(C)C=C2)=NC3=CC=C(C)C=C13
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated


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