Y 11
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CAT No. CS-T-46689
Category Inhibitors
CAS 1086639-59-9
Mol. Weight 265.16 g/mol
Mol. Formula C8H17BrN4O
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Product Description
Stock Status For Exact delivery date, please contact sales@clearsynth.com
Synonyms 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azonia]decane Bromide;(3r,5r,7r)-1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide
Purity (%) >98%
Application Notes Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 M). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
References Xing, Z., et al.: Mol. Biol. Cell, 5, 413 (1994), Halder, J., et al.: Clin. Cancer Res., 11, 8829 (2005), Beierle, E., et al.: J. Biol. Chem., 282, 12503 (2007), Golubovskaya, et al.: J. Med. Chem., 51 7405 (2008),
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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