ClearSolvere® is an expanded venture by Clearsynth. It offers a wide range of products developed in the finest state-of-the-art
manufacturing facility. These products are with maximum isotopic enrichments & are available in competitive prices.
ClearSolvere® team is highly dedicated to work for our customers and deliver them promptly for their demand.
Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 µM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
Xing, Z., et al.: Mol. Biol. Cell, 5, 413 (1994), Halder, J., et al.: Clin. Cancer Res., 11, 8829 (2005), Beierle, E., et al.: J. Biol. Chem., 282, 12503 (2007), Golubovskaya, et al.: J. Med. Chem., 51 7405 (2008),
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy
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