ZM 447439
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CAT No. CS-T-46796
Category Inhibitors
CAS 331771-20-1
Mol. Weight 513.59 g/mol
Mol. Formula C29H31N5O4
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Product Description
Stock Status For Exact delivery date, please contact
Synonyms N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide;N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide
Storage Conditions For long term store at -20°C
Purity (%) >98%
Melting Point (℃)>104 
Solubility DMSO, Methanol
Appearance Pale Yellow Solid
Application Notes It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.
References Ditchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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