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CAS No.
1346604-90-7
Product Code
CS-T-55108
M.F.
C₁₉H₃₀D₄ClNO₂
M.W.
347.96
Category
Stable Isotopes
API Family
Fingolimod
Storage Condition
Store at refrigerator (2-8°C) for long term storage
"Brinkmann, V,, et al,: Transplantation, 72, 764 (2001), Brinkmann, et al,: J, Biol, Chem,, 277, 24, 21453 (2002), Mtaloubian, M,, et al,: Nature, 427, 355 (2004), "
Synonyms
Not available
Application Notes
"A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively)."
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for accurate information.
Overview
"A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively)."
