N-[(7R)-6,7-Dihydro-5-[(4-methoxyphenyl)methyl]-6-oxo-5H-dibenz[b,d]azepin-7-yl]-carbamic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl ester
IMPURITIES    
Availability: Dispatch by : 6-Nov-2019 5:00 PM
CAT No. CS-T-91200
Category Impurities
CAS 1083065-09-1
Mol. Weight 526.67 mol/g
Mol. Formula C₃₃H₃₈N₂O₄
Product Description
Stock Status Dispatch by : 6-Nov-2019 5:00 PM
Solubility Deuterated Chloroform
Appearance Colourless Oil
Application Notes N-[(7R)-6,7-Dihydro-5-[(4-methoxyphenyl)methyl]-6-oxo-5H-dibenz[b,d]azepin-7-yl]-carbamic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl ester is an impurity in the synthesis of (S)-7-Amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for secretase inhibitors for treatment of Alzheimer's disease. Several secretase inhibitors have been described that contain this compound.
Smileys O=C(O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1)N[C@@H]2C3=CC=CC=C3C4=CC=CC=C4N(CC5=CC=C(OC)C=C5)C2=O
COA / MSDS View COA   MSDS
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

c1
ISO 9001:2005
c2
ISO Guide 34:2009
c3
ISO/IEC 17025:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated
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