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Losartan and its related Impurities

Impurities in Losartan can arise during the manufacturing process or storage of the drug.

Last updated on 12-Mar-2023

The most common Losartan Impurities are listed below:

PRODUCT	STRUCTURE
Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan CAT No.: CS-T-16636 CAS Number: 114772-55-3 Category: Losartan Impurities Molecular Formula: C₂₂H₂₂ClN₃O
Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde CAT No.: CS-T-16638 CAS Number: 124750-67-0 Category: Losartan Impurities Molecular Formula: C₂₂H₂₀ClN₃O
Losartan a-Butyl-losartan Aldehyde Adduct Losartan a-Butyl-losartan Aldehyde Adduct CAT No.: CS-T-57302 CAS Number: 1159977-48-6 Category: Losartan Impurities
Losartan Acetyloxy Impurity Losartan Acetyloxy Impurity CAT No.: CS-O-15333 CAS Number: 253678-97-6 Category: Losartan Impurities
Losartan Acetyloxy N1-Trityl Impurity Losartan Acetyloxy N1-Trityl Impurity CAT No.: CS-O-15336 CAS Number: 154709-17-8 Category: Losartan Impurities
Losartan Amine Losartan Amine CAT No.: CS-EO-01398 CAS Number: 141949-89-5 Category: Losartan Impurities Molecular Formula: C₂₂H₂₄ClN₇
Losartan Azide impurity Losartan Azide impurity CAT No.: CS-O-35717 CAS Number: 727718-93-6 Category: Losartan Impurities Molecular Formula: C₂₂H₂₂ClN₉
Losartan Dimer Azide Losartan Dimer Azide CAT No.: CS-EO-02121 CAS Number: 2755908-51-9 Category: Losartan Impurities Molecular Formula: C₄₄H₄₃Cl₂N₁₅
Losartan EP Impurity B Losartan EP Impurity B CAT No.: CS-O-11950 CAS Number: 160514-13-6 Category: Losartan Impurities
Losartan EP Impurity C Losartan EP Impurity C CAT No.: CS-K-00233 CAS Number: 114799-13-2 Category: Losartan Impurities Molecular Formula: ₄₂₂.₉₁ mol/g
Losartan EP Impurity F Losartan EP Impurity F CAT No.: CS-O-15329 CAS Number: 1332713-64-0 Category: Losartan Impurities
Losartan EP Impurity L Losartan EP Impurity L CAT No.: CS-T-57305 CAS Number: 230971-71-8 Category: Losartan Impurities Molecular Formula: C₄₄H₄₄Cl₂N₁₂O
Losartan EP Impurity M Losartan EP Impurity M CAT No.: CS-O-15331 CAS Number: 230971-72-9 Category: Losartan Impurities Molecular Formula: C₄₄H₄₄Cl₂N₁₂O
Losartan Hydroxy N1-Trityl Impurity Losartan Hydroxy N1-Trityl Impurity CAT No.: CS-O-15337 CAS Number: 154709-18-9 Category: Losartan Impurities
Losartan Impurity 1 Losartan Impurity 1 CAT No.: CS-EO-01623 Category: Losartan Impurities Molecular Formula: C₂₂H₂₁ClN₆
Losartan Impurity 15 Losartan Impurity 15 CAT No.: CS-EO-01662 Category: Losartan Impurities Molecular Formula: C₂₂H₂₂ClN₇O₂
Losartan Impurity 5 Losartan Impurity 5 CAT No.: CS-EO-01341 Category: Losartan Impurities Molecular Formula: C₂₂H₂₁ClN₆
Losartan Impurity 6 Losartan Impurity 6 CAT No.: CS-EO-01342 Category: Losartan Impurities Molecular Formula: C₂₂H₂₂ClN₉
Losartan Impurity 7 Losartan Impurity 7 CAT No.: CS-T-88429 CAS Number: 358685-13-9 Category: Losartan Impurities
Losartan Impurity 8 Losartan Impurity 8 CAT No.: CS-EO-01661 Category: Losartan Impurities Molecular Formula: C₂₂H₂₂ClN₇O₂
Losartan isocyano Impurity Losartan isocyano Impurity CAT No.: CS-O-43165 Category: Losartan Impurities Molecular Formula: C₂₂H₂₁ClN₆
Losartan N1-Trityl Impurity Losartan N1-Trityl Impurity CAT No.: CS-O-15330 CAS Number: 124751-00-4 Category: Losartan Impurities Molecular Formula: C₄₁H₃₇ClN₆O
Losartan Potassium EP Impurity A Losartan Potassium EP Impurity A CAT No.: CS-T-09345 CAS Number: 79047-41-9 Category: Losartan Impurities
Losartan Potassium EP Impurity C Losartan Potassium EP Impurity C CAT No.: CS-T-31272 CAS Number: 860644-28-6 Category: Losartan Impurities Molecular Formula: C₂₂H₂₃ClKN₆O
Losartan Potassium EP Impurity E Losartan Potassium EP Impurity E CAT No.: CS-O-11951 CAS Number: 120568-11-8 Category: Losartan Impurities
Losartan Potassium EP Impurity H Losartan Potassium EP Impurity H CAT No.: CS-T-62580 CAS Number: 133909-99-6 Category: Losartan Impurities Molecular Formula: C₄₁H₃₇ClN₆O
Losartan Potassium EP Impurity J Losartan Potassium EP Impurity J CAT No.: CS-T-47310 CAS Number: 1006062-27-6 Category: Losartan Impurities Molecular Formula: C₂₄H₂₅ClN₆O₂
Losartan Potassium EP Impurity K Losartan Potassium EP Impurity K CAT No.: CS-T-31265 CAS Number: 114798-36-6 Category: Losartan Impurities
Losartan Related Compound D Losartan Related Compound D CAT No.: CS-O-36027 CAS Number: 212316-86-4 Category: Losartan Impurities Molecular Formula: C₄₄H₄₃Cl₂KN₁₂O
Losartan Related Compound E Losartan Related Compound E CAT No.: CS-O-36028 CAS Number: 212316-88-6 Category: Losartan Impurities Molecular Formula: C₄₄H₄₃Cl₂KN₁₂O
Nitroso Losartan Nitroso Losartan CAT No.: CS-O-35910 Category: Losartan Impurities Molecular Formula: C₂₂H₂₂ClN₇O₂
N-Trityl Losartan Carboxaldehyde N-Trityl Losartan Carboxaldehyde CAT No.: CS-T-62581 CAS Number: 133910-00-6 Category: Losartan Impurities
N-Trityl Losartan Carboxylic Acid N-Trityl Losartan Carboxylic Acid CAT No.: CS-T-45965 CAS Number: 960231-60-1 Category: Losartan Impurities
N-Trityl Losartan Isomer N-Trityl Losartan Isomer CAT No.: CS-T-45961 CAS Number: 150098-04-7 Category: Losartan Impurities
"Losartan Imidazo[1,5-b]isoquinoline Impurity" "Losartan Imidazo[1,5-b]isoquinoline Impurity" CAT No.: CS-T-57304 CAS Number: 165276-38-0 Category: Losartan Impurities
((2-Butyl-4-chloro-1-((2`-(1-nitroso-1H-tetrazol-5-yl)-[1,1`-biphenyl]-4-yl)methyl)-1H-imidazole-5-yl)methonol) ((2-Butyl-4-chloro-1-((2`-(1-nitroso-1H-tetrazol-5-yl)-[1,1`-biphenyl]-4-yl)methyl)-1H-imidazole-5-yl)methonol) CAT No.: CS-O-40295 Category: Losartan Impurities Molecular Formula: C₂₉H₃₀ClN₇O₄
(2-butyl-4-chloro-1-nitroso-1H-imidazole-5-yl)methanol (2-butyl-4-chloro-1-nitroso-1H-imidazole-5-yl)methanol CAT No.: CS-O-40296 Category: Losartan Impurities Molecular Formula: C₈H₁₂ClN₃O₂
1-Acetyl-6-iodo-1H-indazole 1-Acetyl-6-iodo-1H-indazole CAT No.: CS-O-40131 CAS Number: 850363-52-9 Category: Losartan Impurities Molecular Formula: C₉H₇IN₂O
4-(4-Bromomethylphenyl)benzonitrile 4-(4-Bromomethylphenyl)benzonitrile CAT No.: CS-O-40092 CAS Number: 50670-51-4 Category: Losartan Impurities Molecular Formula: C₁₄H₁₀BrN
5-Iodo-2-methylphenol 5-Iodo-2-methylphenol CAT No.: CS-T-94041 CAS Number: 183803-06-7 Category: Losartan Impurities Molecular Formula: C₇H₇IO

Other Reference Standards of Losartan

PRODUCT	STRUCTURE
Deshydroxymethyl Losartan Trifluoroacetic Acid Salt Deshydroxymethyl Losartan Trifluoroacetic Acid Salt CAT No.: CS-T-52158 Category: Intermediates CAS Number: 1215727-33-5
Losartan Losartan CAT No.: CS-O-10833 Category: API Standards CAS Number: 114798-26-4 Molecular Formula: C₂₂H₂₃ClN₆O
Losartan acid D6 hydrochloride Losartan acid D6 hydrochloride CAT No.: CS-BU-00055 Category: Stable Isotopes
Losartan Acyl-β-D-glucuronide Losartan Acyl-β-D-glucuronide CAT No.: CS-O-05703 Category: Glucuronides CAS Number: 1799830-02-6 Molecular Formula: C₂₈H₂₉ClN₆O₈
Losartan azide-d8 Losartan azide-d8 CAT No.: CS-O-40065 Category: Stable Isotopes Molecular Formula: C₂₂H₁₄D₈ClN₉
Losartan carboxylic acid Losartan carboxylic acid CAT No.: CS-O-10324 Category: Metabolites CAS Number: 124750-92-1 Molecular Formula: C₂₂H₂₁ClN₆O₂
Losartan Carboxylic acid D4 Losartan Carboxylic acid D4 CAT No.: CS-O-06731 Category: Stable Isotopes CAS Number: 1246820-62-1 Molecular Formula: C₂₂H₁₇D₄ClN₆O₂
Losartan D2 Losartan D2 CAT No.: CS-O-02734 Category: Stable Isotopes CAS Number: 1030936-22-1 Molecular Formula: C₂₂H₂₁D₂ClN₆O
Losartan D3 Losartan D3 CAT No.: CS-T-57300 Category: Stable Isotopes CAS Number: 1030936-74-3
Losartan D4 Losartan D4 CAT No.: CS-O-02637 Category: Stable Isotopes CAS Number: 1030937-27-9 Molecular Formula: C₂₂H₁₉D₄ClN₆O
Losartan for system suitability (Y0001076) Losartan for system suitability (Y0001076) CAT No.: CS-EG-02921 Category: EP Standards Molecular Formula: C₂₂H₂₃ClN₆O
Losartan impurity D (Y0001072) Losartan impurity D (Y0001072) CAT No.: CS-EG-02923 Category: EP Standards CAS Number: 83857-96-9 Molecular Formula: C₈H₁₁ClN₂O
Losartan N1-Glucuronide Losartan N1-Glucuronide CAT No.: CS-O-07894 Category: Glucuronides CAS Number: 138584-34-6 Molecular Formula: C₂₈H₃ClN₆O₇
Losartan N2-glucuronide Losartan N2-glucuronide CAT No.: CS-P-05197 Category: Glucuronides
Losartan N2-β-D-glucuronide Losartan N2-β-D-glucuronide CAT No.: CS-O-30518 Category: Glucuronides CAS Number: 138584-35-7 Molecular Formula: C₂₈H₃₁ClN₆O₇
Losartan potassium Losartan potassium CAT No.: CS-O-01767 Category: API Standards CAS Number: 124750-99-8 Molecular Formula: C₂₂H₂₂ClKN₆O
Losartan Potassium (H1M331) Losartan Potassium (H1M331) CAT No.: CS-EB-01226 Category: USP Standards CAS Number: 124750-99-8
Losartan potassium (Y0001062) Losartan potassium (Y0001062) CAT No.: CS-EG-02959 Category: EP Standards CAS Number: 124750-99-8 Molecular Formula: C₂₂H₂₃ClKN₆O
Losartan Potassium(Secondary Standards traceble to USP) Losartan Potassium(Secondary Standards traceble to USP) CAT No.: CS-ER-01221 Category: Secondary Standards CAS Number: 124750-99-8
Losartan Related Compound A(Secondary Standards traceble to USP) Losartan Related Compound A(Secondary Standards traceble to USP) CAT No.: CS-ER-01222 Category: Secondary Standards CAS Number: 83857-96-9
Losartan Related Compound B(Secondary Standards traceble to USP) Losartan Related Compound B(Secondary Standards traceble to USP) CAT No.: CS-ER-01223 Category: Secondary Standards CAS Number: 1006062-27-6
Losartan Related Compound C(Secondary Standards traceble to USP) Losartan Related Compound C(Secondary Standards traceble to USP) CAT No.: CS-ER-01217 Category: Secondary Standards CAS Number: 114798-36-6
Losartan Related Compound D (F01160) Losartan Related Compound D (F01160) CAT No.: CS-EB-01230 Category: USP Standards CAS Number: 212316-86-4 Molecular Formula: C₄₄H₄₃Cl₂KN₁₂O
Losartan Related Compound D(Secondary Standards traceble to USP) Losartan Related Compound D(Secondary Standards traceble to USP) CAT No.: CS-ER-01218 Category: Secondary Standards CAS Number: 212316-86-4
Losartan Related Compound E (F01170) Losartan Related Compound E (F01170) CAT No.: CS-EB-01231 Category: USP Standards CAS Number: 212316-88-6 Molecular Formula: C₄₄H₄₃Cl₂KN₁₂O
Losartan Related Compound E(Secondary Standards traceble to USP) Losartan Related Compound E(Secondary Standards traceble to USP) CAT No.: CS-ER-01219 Category: Secondary Standards CAS Number: 212316-88-6
Losartan Trityl Ether Losartan Trityl Ether CAT No.: CS-T-57303 Category: Intermediates CAS Number: 1006062-28-7
Losartan-d3 Carboxylic Acid Losartan-d3 Carboxylic Acid CAT No.: CS-T-57301 Category: Stable Isotopes CAS Number: 1189729-40-5
N-1-Ethoxyethyl Losartan Carboxaldehyde N-1-Ethoxyethyl Losartan Carboxaldehyde CAT No.: CS-T-22366 Category: Intermediates CAS Number: 165276-40-4
N-1-Ethoxyethyl Losartan Carboxylic Acid N-1-Ethoxyethyl Losartan Carboxylic Acid CAT No.: CS-T-22367 Category: Intermediates CAS Number: 165276-41-5
N-Trityl-deshydroxymethyl Losartan N-Trityl-deshydroxymethyl Losartan CAT No.: CS-T-88136 Category: Intermediates CAS Number: 1797133-13-1
Trityl-Losartan D4 Trityl-Losartan D4 CAT No.: CS-Y-00101 Category: Stable Isotopes CAS Number: 1309283-24-6
ω-1-Hydroxy Losartan ω-1-Hydroxy Losartan CAT No.: CS-T-56163 Category: Intermediates CAS Number: 141675-57-2
2-Butyl-4-chloro-5-formylimidazole 2-Butyl-4-chloro-5-formylimidazole CAT No.: CS-O-31530 Category: Intermediates CAS Number: 83857-96-9 Molecular Formula: C₈H₁₁ClN₂O
5-Deshydroxymethyl-5-chloro Losartan 5-Deshydroxymethyl-5-chloro Losartan CAT No.: CS-T-52157 Category: Intermediates CAS Number: 1159977-26-0
ω-3-Hydroxy Losartan ω-3-Hydroxy Losartan CAT No.: CS-T-79242 Category: Intermediates CAS Number: 141675-59-4