Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain and is taken by mouth. It is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotics.
Metformin is generally well tolerated. Common adverse effects include diarrhea, nausea, and abdominal pain. It has a small risk of causing low blood sugar. High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. It is not recommended in those with significant liver disease.
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Other Reference Standards of Metformin
What is Metformin Impurities?
- Metformin Impurities are the components of Metformin which are not the defined active substance of Metformin
- They are unwanted chemicals that remain with active pharmaceutical ingredients of Metformin
- Some of Metformin Impurities can be used for evaluating data that establishes quality
- They are also used for stability and biological safety of pharmaceutical products
- Metformin Impurities can also be used for ANDA / DMF filling and genotoxicity studies.
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