Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disease, and vitiligo. It can be used to treat dry eye syndrome in cats and dogs.
Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body's learned (or adaptive) immune response.
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Other Reference Standards of Tacrolimus
What is Tacrolimus Impurities?
- Tacrolimus Impurities are the components of Tacrolimus which are not the defined active substance of Tacrolimus
- They are unwanted chemicals that remain with active pharmaceutical ingredients of Tacrolimus
- Some of Tacrolimus Impurities can be used for evaluating data that establishes quality
- They are also used for stability and biological safety of pharmaceutical products
- Tacrolimus Impurities can also be used for ANDA / DMF filling and genotoxicity studies.
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