Tacrolimus Metabolites


Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disease, and vitiligo. It can be used to treat dry eye syndrome in cats and dogs.

Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body's learned (or adaptive) immune response.



List of Metabolites of Tacrolimus



Other Reference Standards of Tacrolimus


CAT No. COMPOUND CATEGORY IMAGE
CS-ED-00227 Oxacyclohexane Open Ring Tacrolimus Tacrolimus Impurities Oxacyclohexane Open Ring Tacrolimus
CS-O-30787 Tacrolimus Tacrolimus API Standards Tacrolimus
CS-EB-02308 Tacrolimus (1642802) Tacrolimus USP Standards Tacrolimus (1642802)
CS-O-03122 Tacrolimus 13CD2 Tacrolimus Stable Isotopes Tacrolimus 13CD2
CS-O-33256 Tacrolimus 21-carboxylic acid Tacrolimus Impurities Tacrolimus 21-carboxylic acid
CS-ER-02046 Tacrolimus 8-epimer(Secondary Standards traceble to USP) Tacrolimus Secondary Standards Tacrolimus 8-epimer(Secondary Standards traceble to USP)
CS-O-08221 Tacrolimus 8-Propyl Analog Tacrolimus Impurities Tacrolimus 8-Propyl Analog
CS-EB-02852 Tacrolimus 8-Propyl Analog (1642835) Tacrolimus USP Standards Tacrolimus 8-Propyl Analog (1642835)
CS-P-08636 Tacrolimus alpha-Hydroxy Acid (TAC-H1) Tacrolimus Impurities Tacrolimus alpha-Hydroxy Acid (TAC-H1)
CS-EO-00669 Tacrolimus Dehydro Impurity Tacrolimus Impurities Tacrolimus Dehydro Impurity
CS-P-00144 Tacrolimus Diene Tacrolimus Impurities Tacrolimus Diene
CS-EO-01090 Tacrolimus EP Impurity B Tacrolimus Impurities Tacrolimus EP Impurity B
CS-EO-01091 Tacrolimus EP Impurity F Tacrolimus Impurities Tacrolimus EP Impurity F
CS-P-08338 Tacrolimus EP Impurity H Tacrolimus Impurities Tacrolimus EP Impurity H
CS-EG-01239 Tacrolimus for system suitability (Y0001933) Tacrolimus EP Standards Tacrolimus for system suitability (Y0001933)
CS-P-08339 Tacrolimus Impurity 18 Tacrolimus Impurities Tacrolimus Impurity 18
CS-O-38229 Tacrolimus Impurity 39 Tacrolimus Impurities Tacrolimus Impurity 39
CS-P-02134 Tacrolimus Impurity 6 Tacrolimus Impurities Tacrolimus Impurity 6
CS-P-08639 Tacrolimus Impurity III Tacrolimus Impurities Tacrolimus Impurity III
CS-EO-01009 Tacrolimus Impurity VII Tacrolimus Impurities Tacrolimus Impurity VII
CS-T-59735 Tacrolimus impurity-1 Tacrolimus Impurities Tacrolimus impurity-1
CS-O-08222 Tacrolimus Lactone Isomer Tacrolimus Impurities Tacrolimus Lactone Isomer
CS-T-61570 Tacrolimus Methyl Acryl Aldehyde Tacrolimus Impurities Tacrolimus Methyl Acryl Aldehyde
CS-O-08223 Tacrolimus Monohydrate Tacrolimus API Standards Tacrolimus Monohydrate
CS-EG-02488 Tacrolimus monohydrate (Y0001926) Tacrolimus EP Standards Tacrolimus monohydrate (Y0001926)
CS-O-34798 Tacrolimus Regioisomer Tacrolimus Impurities Tacrolimus Regioisomer
CS-O-35447 Tacrolimus Related Compound A Tacrolimus Impurities Tacrolimus Related Compound A
CS-P-08282 Tacrolimus Ring-opening Impurity Tacrolimus Impurities Tacrolimus Ring-opening Impurity
CS-ER-02814 Tacrolimus(Secondary Standards traceble to USP) Tacrolimus Secondary Standards Tacrolimus(Secondary Standards traceble to USP)
CS-O-13614 Tacrolimus-13CD4 Tacrolimus Stable Isotopes Tacrolimus-13CD4
CS-O-33831 10-demetyl Tacrolimus Tacrolimus Impurities 10-demetyl Tacrolimus
CS-T-53956 8-Epitacrolimus Tacrolimus Impurities 8-Epitacrolimus


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