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Clearsynth offers a large selection of deuterated reagents, which are used in the field of deuterium labeled APIs, also known as deuterated drugs. Our production capacity allows us to support customer projects from R&D through clinical phases to market introduction.
A deuterated API is a small molecule-active substance in which one or more of the hydrogen atoms are replaced by its heavier isotope deuterium. Because of the kinetic isotope effect, the drugs may have significantly lower rates of metabolism and a longer half-life.
Based on those facts, the benefit can be smaller or fewer dosages and reduced side effects. The potential advantages of deuterated pharmaceuticals includes: 1. Improved metabolic profile. The improved metabolic profile may potentially reduce or eliminate unwanted side effects or undesirable drug interactions. 2. Improved oral bioavailability. Deuteration in some compounds has reduced the presystemic metabolism that occurs in the digestive track, allowing more of the unmetabolized drug to reach its target. 3. Increased half-le.
Deuterated compounds can have a slower pharamacokinetic affect, extending the absorption and distribution in the body. This may decrease the number of doses a patient may require in certain time period compared to its nondeuterated counterpart.