Deuterated Reagents


Deuterated Reagents reference standards

Clearsynth offers a large selection of deuterated reagents, which are used in the field of deuterium labeled APIs, also known as deuterated drugs. Our production capacity allows us to support customer projects from R&D through clinical phases to market introduction. A deuterated API is a small molecule-active substance in which one or more of the hydrogen atoms are replaced by its heavier isotope deuterium. Because of the kinetic isotope effect, the drugs may have significantly lower rates of metabolism and a longer half-life.

Based on those facts, the benefit can be smaller or fewer dosages and reduced side effects. The potential advantages of deuterated pharmaceuticals includes: 1. Improved metabolic profile. The improved metabolic profile may potentially reduce or eliminate unwanted side effects or undesirable drug interactions. 2. Improved oral bioavailability. Deuteration in some compounds has reduced the presystemic metabolism that occurs in the digestive track, allowing more of the unmetabolized drug to reach its target. 3. Increased half-le.

Deuterated compounds can have a slower pharamacokinetic affect, extending the absorption and distribution in the body. This may decrease the number of doses a patient may require in certain time period compared to its nondeuterated counterpart.



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CAT No. COMPOUND CATEGORY
CS-C-00320 Acenaphthene-d10 Deuterated Reagents
CS-T-46900 Acenaphthylene d8 Deuterated Reagents
CS-T-46912 Acetaldehyde D4 Deuterated Reagents
CS-O-10922 Acetic Acid D4 Deuterated Reagents
CS-O-10922-10 × 0.75mL Acetic Acid D4 Deuterated Reagents
CS-O-10922-10mL Acetic Acid D4 Deuterated Reagents
CS-T-64496 Acetic Acid-?d Deuterated Reagents
CS-BX-00897 Acetic acid-d Deuterated Reagents
CS-O-10852 Acetic Anhydride D6 Deuterated Reagents
CS-T-46994 Acetone D6 Deuterated Reagents
CS-T-46994-10mL Acetone D6 Deuterated Reagents
CS-T-46997-10mL Acetonitrile D3 Deuterated Reagents
CS-T-46997 Acetonitrile D3 Deuterated Reagents
CS-T-46999 Acetophenone D8 Deuterated Reagents
CS-T-47007 Acetyl-d3 Chloride Deuterated Reagents
CS-O-06385 Albuterol D9 Deuterated Reagents
CS-T-48157 Ammonium 15N Chloride Deuterated Reagents
CS-CE-00844 Ammonium-D4 formate-D Deuterated Reagents
CS-T-48263 Aniline D7 Deuterated Reagents
CS-T-66681 Anthracene D10 Deuterated Reagents
CS-O-06413 Aripiprazole D8 Deuterated Reagents
CS-T-95569 Benz[a]anthracene-d12 Deuterated Reagents
CS-O-14865 Benzaldehyde D6 Deuterated Reagents
CS-O-11242-50GM Benzene D6 Deuterated Reagents
CS-BX-01138 Benzene D6 10g Pack Deuterated Reagents
CS-O-11242-10GM Benzene D6 -10g Pack Deuterated Reagents
CS-O-41560 Benzene D6 D-Atom 99.5% Deuterated Reagents
CS-O-11242 Available in Bulk Benzene-d6 Deuterated Reagents
CS-C-00282 Benzo[a]pyrene-d12 Deuterated Reagents
CS-C-00241 Benzo[g,h,i]perylene-d12 Deuterated Reagents
CS-T-48655 Benzocaine D4 Deuterated Reagents
CS-T-48678 Available in Bulk Benzoic Acid D5 Deuterated Reagents
CS-T-68679 Borane-d3 (1M in THF) Deuterated Reagents
CS-O-10893 Available in Bulk Bromobenzene D5 Deuterated Reagents
CS-T-49720 Bromoethane D5 Deuterated Reagents
CS-BX-00302 Butyric acid D7 Deuterated Reagents
CS-T-50251 Carbendazim D4 Deuterated Reagents
CS-T-50281 Carbofuran D3 Deuterated Reagents
CS-T-50563 Chlorobenzene D5 Deuterated Reagents
CS-O-40752 Chloroform D + 0.03% TMS Deuterated Reagents
CS-T-50737 Available in Bulk Chloroform-d Deuterated Reagents
CS-O-42122 Chloroform-D stabilized -10g Pack Deuterated Reagents
CS-O-42123-100G Chloroform-D stabilized-100g Pack Deuterated Reagents
CS-O-42121-100G Chloroform-D with 0.03 v/v% TMS stabilized-100g Pack Deuterated Reagents
CS-O-42120 Chloroform-D with 0.03 v/v% TMS stabilized-10g Pack Deuterated Reagents
CS-P-00883 Chlorpyriphos D10 Deuterated Reagents
CS-T-50923 Chrysene D12 Deuterated Reagents
CS-W-00020 Cimaterol D7 Deuterated Reagents
CS-I-00570 Cortisol-[d4] (Solution) Deuterated Reagents
CS-T-51278 Cotinine-β-D-Glucuronide Deuterated Reagents
CS-O-01225 Cotinine-d3 Deuterated Reagents
CS-CE-00836 Cyclohexane-D12 Deuterated Reagents
CS-O-06528 Dapsone D8 Deuterated Reagents
CS-CE-00819 Decahydronaphthalene-D18 Deuterated Reagents
CS-CE-00820 Decane-D22 Deuterated Reagents
CS-CE-00821 Available in Bulk Deuterium Bromide Deuterated Reagents
CS-T-52330 Available in Bulk Deuterium Chloride Deuterated Reagents
CS-T-88811 Dibutyl Phthalate-d4 Deuterated Reagents
CS-T-53361 Dimethyl Sulfate D6 Deuterated Reagents
CS-T-53699 Dimethyl Sulfoxide D6 Deuterated Reagents
CS-T-53699-10G Dimethyl Sulfoxide D6 - 10g Pack Deuterated Reagents
CS-T-53699-50G Dimethyl Sulfoxide D6 - 50g Pack Deuterated Reagents
CS-BX-01140 Dimethyl Sulfoxide D6 - 50g Pack Deuterated Reagents
CS-O-44175 Dimethyl Sulfoxide D6 40% solution in D2O Deuterated Reagents
CS-T-40753-10G Dimethyl Sulfoxide D6 with 0.03 v/v% TMS - 10g Pack Deuterated Reagents
CS-T-40753-50G Dimethyl Sulfoxide D6 with 0.03 v/v% TMS - 50g Pack Deuterated Reagents
CS-O-03137 Available in Bulk Dimethylamine D6 Hydrochloride Deuterated Reagents
CS-T-53762 Di-n-octyl Phthalate D4 Deuterated Reagents
CS-O-11247 DMF D7 Deuterated Reagents
CS-T-54063 Epichlorohydrin D5 Deuterated Reagents
CS-T-54273 Estrone D4 Deuterated Reagents
CS-CE-00835 Ethanol-D6 Deuterated Reagents
CS-T-54279 Ethanol-OD Deuterated Reagents
CS-T-22813 Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate-d6 Deuterated Reagents
CS-BX-00346 Ethyl acetate D8 Deuterated Reagents
CS-CE-00837 Ethylbenzene-D10 Deuterated Reagents
CS-T-54971 Flurbiprofen D3 Deuterated Reagents
CS-T-55022 Formic Acid-d2 Deuterated Reagents
CS-T-55133 Furan D4 Deuterated Reagents
CS-O-06657 Haloperidol D4 Deuterated Reagents
CS-CE-00840 Hexafluoroisopropanol-D2 Deuterated Reagents
CS-O-02905 Hydrocortisone D4 Deuterated Reagents
CS-T-56509 Hydroxy Tolbutamide D9 Deuterated Reagents
CS-O-10421 Available in Bulk Iodomethane-d3 Deuterated Reagents
CS-CE-00827 Isopropanol-D8 Deuterated Reagents
CS-T-57278 Lithium Aluminum Deuteride Deuterated Reagents
CS-CE-00855 Lithium deuteride Deuterated Reagents
CS-T-57461 Melamine D6 Deuterated Reagents
CS-CE-00857 Mesitylene-D12 Deuterated Reagents
CS-R-00471 METHANOL D3 Deuterated Reagents
CS-T-57790-10G Methanol D4 -10ml Pack Deuterated Reagents
CS-BX-01142 Methanol D4 -10ml Pack Deuterated Reagents
CS-O-40817 Methanol D4 with 0.03 v/v% TMS - 10ml Pack Deuterated Reagents
CS-O-40817-10G Methanol D4 with 0.03 v/v% TMS - 10ml Pack Deuterated Reagents
CS-O-10920 Available in Bulk Methanol-OD Deuterated Reagents
CS-T-57790 Methyl Alcohol D4 Deuterated Reagents
CS-T-82403 Methyl Formate-d Deuterated Reagents
CS-CE-00829 Methylcyclohexane-D14 Deuterated Reagents
CS-T-33750 Methylene Chloride-d2 Deuterated Reagents
CS-O-15212 Available in Bulk Naphthalene D8 Deuterated Reagents
CS-CE-00818 n-Butanol-D10 Deuterated Reagents
CS-CE-00838 n-Heptane-D16 Deuterated Reagents
CS-CE-00825 n-Hexane-D14 Deuterated Reagents
CS-O-02999 Nicotinamide D4 Deuterated Reagents
CS-O-02825 Nicotinic acid D4 Deuterated Reagents
CS-CE-00859 Nitric Acid-D Deuterated Reagents
CS-T-59336 Nitrobenzene D5 Deuterated Reagents
CS-CE-00853 Nitromethane-D3 Deuterated Reagents
CS-T-59622 N-Nitrosodimethylamine D6 Deuterated Reagents
CS-O-38852 N-Nitrosodimethylamine D6 (1000 ppm in methanol) Deuterated Reagents
CS-O-38657 N-Nitrosodimethylamine D6 1000 µg/mL in Methanol Deuterated Reagents
CS-O-34890 N-Nitrosodimethylamine D6 5MG/ML In Methanol Deuterated Reagents
CS-T-94778 N-Nitrosodimethylamine-d6 (1.0 mg/mL in Methanol) Deuterated Reagents
CS-O-02685 N'-Nitrosonornicotine-2,4,5,6-d4(pyridine-d4) Deuterated Reagents
CS-CE-00831 n-Octane-D18 Deuterated Reagents
CS-R-00214 N-PENTANE-D12 D Deuterated Reagents
CS-C-00814 n-Tetracosane-d50 Deuterated Reagents
CS-O-14867 Ortho-Xylene-D10 Deuterated Reagents
CS-C-00850 o-Xylene-d10 Deuterated Reagents
CS-O-14657 Paraformaldehyde-d2 Deuterated Reagents
CS-BX-00366 Phenylacetylene D6 Deuterated Reagents
CS-R-00643 PROPIONIC ACID D6 Deuterated Reagents
CS-O-03093 Propranolol D7 Deuterated Reagents
CS-O-11245 P-Terphenyl-d14 Deuterated Reagents
CS-T-60910 Pyrene D10 Deuterated Reagents
CS-O-14550 Pyridine-d5 Deuterated Reagents
CS-O-14550-10 × 0.75mL Pyridine-d5 Deuterated Reagents
CS-O-14550-10mL Pyridine-d5 Deuterated Reagents
CS-T-60945 Pyridine-N-oxide D5 Deuterated Reagents
CS-T-59260 rac-Nicotine D4 Deuterated Reagents
CS-T-61435 Styrene D8 Deuterated Reagents
CS-T-61512 Sulfadimidine D4 Deuterated Reagents
CS-O-13174 Available in Bulk Sulfuric Acid D2 Deuterated Reagents
CS-T-61652 Terephthalic-d4 Acid Deuterated Reagents
CS-O-11464 Tert-butanol-d10 Deuterated Reagents
CS-T-61658 Tert-butyl Alcohol-OD Deuterated Reagents
CS-T-61817 Tetrahydrofuran D8 Deuterated Reagents
CS-T-61817-10 × 0.75mL Tetrahydrofuran D8 Deuterated Reagents
CS-T-61817-10mL Tetrahydrofuran D8 Deuterated Reagents
CS-T-62117-10 × 0.75mL Toluene D8 Deuterated Reagents
CS-T-62117-10mL Toluene D8 Deuterated Reagents
CS-T-62117 Toluene D8 Deuterated Reagents
CS-T-55903 trans-3-Hydroxy Cotinine-d3 Deuterated Reagents
CS-CE-00812 Trifluoroacetic acid-D Deuterated Reagents
CS-CE-00812-10 × 0.75mL Trifluoroacetic acid-D1 Deuterated Reagents
CS-CE-00812-10mL Trifluoroacetic acid-D1 Deuterated Reagents
CS-O-42176 Trifluoromethanesulfonic acid-d Deuterated Reagents
CS-T-62274 Tri-n-butyltin Deuteride Deuterated Reagents
CS-CE-00858 1,1,2,2-Tetrachloroethane-D2 Deuterated Reagents
CS-T-52560 1,2-Dichlorobenzene D4 Deuterated Reagents
CS-CE-00846 1,4-Dibromobenzene-D4 Deuterated Reagents
CS-CE-00809 1,4-Xylene-D10 Deuterated Reagents
CS-T-49975 1-Butanol-d Deuterated Reagents
CS-O-42637 2% w/w Dimethyl Sulfoxide solution in Deuterium Oxide Deuterated Reagents
CS-BX-00324 2,2,2-Trifluoroethanol-D3 Deuterated Reagents
CS-T-47940 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-d3 Deuterated Reagents
CS-C-00005 2-Bromotoluene-d7 Deuterated Reagents
CS-T-59142 2-Naphthylamine D7 Deuterated Reagents
CS-T-62496 3-(Trimethylsilyl)propionic Acid-d4 Sodium Salt Deuterated Reagents
CS-T-50973 3-Chloro-1,2-propanediol D5 Deuterated Reagents