| Catalog Number CS-T-72894 |
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| CAS Number 7424-00-2 |
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| Status Available |
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| Category Intermediates, Amino Acids and Derivatives |
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Hazardous Compound |
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| Controlled Substance No |
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| IUPAC Name 2-amino-3-(4-chlorophenyl)propanoic acid |
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| Exact Mass 199.0400063 |
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| Color Crystals from methanol |
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| Melting Point 238-240 °C |
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| Solubility In water, 961 mg/L at 25 °C (est) |
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| Hazard Class Acute Tox. 3 (100%) |
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| Description 2-amino-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative. |
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| Vapor Pressure 6.09X10-9 mm Hg at 25 °C (est) |
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| Antidoteand Emergency Treatment /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/ |
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| Human Toxicity Excerpts /SIGNS AND SYMPTOMS/ Some of the mystery surrounding serotonin has been unraveled recently after the development of a means of selectively depriving the organism of this amine. Key aspects of recent advances include biochemical characterization of the first enzymatic step in tissue serotonin biosynthesis, that of tryptophan 5-hydroxylation; discovery of an inhibitor (para-chlorophenylalanine (PCPA)) of the reaction; and observations on the effects of serotonin deprival as produced by PCPA in man and animals. Control of diarrhea in the carcinoid syndrome by PCPA treatment indicates that the major target organ of circulating serotonin is the intestinal tract. Induction of psychiatric effects with high doses of PCPA, along with other evidence, is compatible with a serotonin-deficiency hypothesis of affective illness. Serotonin plays a role in sleep mechanisms, with PCPA suppressing and 5-hydroxytryptophan (serotonin precursor) restoring rapid eye movement sleep in man. Finally, animal data raise exciting possibilities of the involvement of brain serotonin in control of sexual behavior. |
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