Dofetilide is an antiarrhythmic drug used to treat atrial fibrillation. Dofetilide impurities are unwanted substances that can be present in the drug product, either as by-products of the manufacturing process or through degradation. These impurities can affect the potency, stability, and safety of the drug, and therefore must be monitored and controlled to ensure the quality and efficacy of the medication. The identification and quantification of these impurities is crucial for regulatory compliance and patient