Entrectinib is a medication used in the treatment of certain types of cancer. However, during the manufacturing process of entrectinib, impurities may be produced which can affect the safety and efficacy of the drug. These impurities can be harmful to human health and therefore must be identified and controlled to ensure the safety and quality of the medication. Control of impurities is an important aspect of drug development and manufacturing to ensure the safety and efficacy of pharmaceutical products.