[13C3,15N]-Triapine

[13C3,15N]-Triapine is a chemical compound that has gained attention in recent years due to its potential in cancer treatment. It is a modified version of the original Triapine, which was discovered to inhibit the enzyme ribonucleotide reductase (RNR), an important enzyme in DNA synthesis. However, the modified version contains three carbon atoms and one nitrogen atom that are isotopically labeled with carbon-13 and nitrogen-15, respectively. The isotopic labeling of [13C3,15N]-Triapine allows for its detection and tracking in vivo using techniques such as mass spectrometry. This is particularly useful in cancer research, as it enables researchers to study the distribution and metabolism of the compound within cells and tissues. Studies have shown that [13C3,15N]-Triapine is effective in inhibiting cancer cell growth in various types of cancer, including leukemia, lung cancer, and ovarian cancer. Its mechanism of action involves disrupting the DNA synthesis process, leading to cell death. It is important to note that [13C3,15N]-Triapine is still in the early stages of research and development, and its safety and efficacy in human trials are yet to be fully established. Nonetheless, its potential in cancer treatment makes it a promising candidate for further investigation.