(2S,3S,11bS)-Dihydrotetrabenazine-d6

(2S,3S,11bS)-Dihydrotetrabenazine-d6 is a deuterated analog of Dihydrotetrabenazine, a medication used to treat hyperkinetic movement disorders such as chorea associated with Huntington's disease. This compound is a labeled isotopologue, meaning that it contains six deuterium atoms instead of the usual hydrogen atoms. The deuterium atoms do not significantly alter the chemical properties or therapeutic effects of the parent compound, but they can be used in studies to track the distribution, metabolism, and elimination of the drug in the body. The chemical formula of (2S,3S,11bS)-Dihydrotetrabenazine-d6 is C19H22D6N2O2, and its molecular weight is 318.50 g/mol. It is a white to off-white powder that is soluble in organic solvents such as methanol and ethanol but insoluble in water. The compound is stable under normal conditions but should be stored in a cool, dry place away from heat and light. (2S,3S,11bS)-Dihydrotetrabenazine-d6 is primarily used in pharmacokinetic and pharmacodynamic studies to determine the concentration and activity of Dihydrotetrabenazine in biological samples. It can be administered orally or intravenously to human or animal subjects, and its concentration can be measured using techniques such as gas chromatography-mass spectrometry or liquid chromatography-tandem mass spectrometry. By using labeled isotopologues such as (2S,3S,11bS)-Dihydrotetrabenazine-d6, researchers can gain valuable insights into the metabolism, distribution, and elimination of drugs in vivo.