(4-Carboxybutyl-d4)triphenylphosphonium Bromide

(4-Carboxybutyl-d4)triphenylphosphonium Bromide is a deuterated phosphonium salt with the chemical formula C25H21BrD4O2P. It is a useful compound in biochemical research as a tool for studying mitochondrial membrane potential and for investigating the activity of the respiratory chain complex. The compound is commonly used in fluorescence-based assays to measure mitochondrial membrane potential. It works by selectively accumulating in the negatively charged mitochondrial matrix, where it is concentrated by a potential-dependent mechanism. The compound's fluorescence is sensitive to changes in mitochondrial membrane potential, allowing researchers to monitor the activity of the respiratory chain complex. (4-Carboxybutyl-d4)triphenylphosphonium Bromide is also used in studies investigating mitochondrial dysfunction and the role of mitochondrial membrane potential in cellular processes such as apoptosis and necrosis. It has been shown to induce apoptosis in cancer cells by disrupting mitochondrial membrane potential, making it a promising candidate for cancer therapy. In terms of chemical properties, (4-Carboxybutyl-d4)triphenylphosphonium Bromide is a highly soluble salt that is stable under normal laboratory conditions. It is typically stored at -20°C and should be protected from light and moisture to prevent degradation. Overall, (4-Carboxybutyl-d4)triphenylphosphonium Bromide is a valuable tool for studying mitochondrial function and dysfunction in a variety of biological systems.