(5-amino-2(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione)

5-amino-2(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, also known as SU5416, is a synthetic organic compound with a molecular formula of C20H14N2O5. It is a potent inhibitor of vascular endothelial growth factor receptor (VEGFR) and has been extensively studied as a potential anti-cancer drug. SU5416 works by targeting the VEGFR, which is a key receptor in the process of angiogenesis, or the formation of new blood vessels. By inhibiting the VEGFR, SU5416 prevents the growth and spread of cancer cells that rely on angiogenesis to survive and proliferate. It has been shown to have efficacy against a variety of cancer types, including lung cancer, breast cancer, and colon cancer. In addition to its anti-cancer properties, SU5416 has also been studied for its potential in treating other diseases such as age-related macular degeneration and diabetic retinopathy. However, due to its potent inhibition of VEGFR, SU5416 has also been associated with several adverse effects, including hypertension, bleeding, and thrombosis. Overall, SU5416 is a promising compound with potential therapeutic applications in cancer and other diseases. However, further research is needed to fully understand its mechanisms of action and to optimize its safety and efficacy.