(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid

(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid, also known as Boc-Val-Cit-PAB, is a chemical compound that is commonly used in the field of biochemistry and biotechnology. The compound is a derivative of the amino acid valine and contains a carbamate group, which makes it useful for conjugating with other molecules. Boc-Val-Cit-PAB is commonly used as a linker molecule in antibody-drug conjugates (ADCs), which are a class of drugs used in cancer treatment. The compound is used to conjugate the cytotoxic drug to the antibody, which allows for targeted delivery of the drug to cancer cells while minimizing damage to healthy cells. The chemical structure of Boc-Val-Cit-PAB includes a tert-butoxycarbonyl (Boc) protecting group, which is used to protect the amino group of the valine residue during synthesis. The compound also contains a citrulline (Cit) residue, which has been shown to improve the stability and efficacy of ADCs. In addition to its use in ADCs, Boc-Val-Cit-PAB has also been studied for its potential use in targeted drug delivery for other diseases, such as viral infections and autoimmune disorders. The compound's unique chemical structure and ability to conjugate with other molecules make it a promising candidate for future drug development.