1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(2-hydroxyethyl)-3-nitrosourea
Also known as: - Nitrosamine Impurities or nitrosamine impurities of -| Product Name | 1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(2-hydroxyethyl)-3-nitrosourea |
|---|---|
| Alternate Names | - Impurities, Impurities of - |
| CAT No. | CS-O-44380 |
| CAS No. | 89854-43-3 |
| Category | Impurities |
| Stock | Enquire |
| Mol. Wt. | 243.18 g/mol |
| Mol. For. | C7H9N5O5 |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | - |
| Controlled | No |
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1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(2-hydroxyethyl)-3-nitrosourea is a chemical compound that is used in the medical field as an alkylating agent in chemotherapy. It is commonly referred to as DTIC (Dacarbazine) and is used to treat various types of cancer, such as melanoma and Hodgkin's lymphoma.
The chemical structure of DTIC consists of a nitrosourea functional group, which is known for its ability to alkylate DNA and RNA. This process leads to the formation of covalent bonds between the drug and the nucleic acid, which ultimately results in the inhibition of DNA synthesis and cell division. The pyrimidine ring in the molecule also contributes to the cytotoxicity of the drug by inducing DNA damage.
DTIC is administered intravenously and is rapidly metabolized in the liver to its active form. The drug is eliminated from the body through the kidneys and has a short half-life of approximately 20 minutes.
While DTIC is an effective chemotherapy drug, it does have side effects, including nausea, vomiting, and myelosuppression (a decrease in blood cell production). However, these side effects can be managed through supportive care and dose adjustments.
In conclusion, 1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(2-hydroxyethyl)-3-nitrosourea, or DTIC, is a chemical compound used in chemotherapy to treat cancer. Its mechanism of action involves the alkylation of DNA and RNA, ultimately leading to the inhibition of cell division. While it does have side effects, it remains an important tool in the fight against cancer.
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