1-Methyl-4-nitrosopiperazine-D8

1-Methyl-4-nitrosopiperazine-D8 (MNPP-D8) is a deuterated derivative of 1-Methyl-4-nitrosopiperazine (MNPP), a nitrosamine compound. It is commonly used as a reference standard in analytical chemistry and biochemistry applications, including drug development and toxicology studies. The deuterium substitution in MNPP-D8 is used to improve the sensitivity and accuracy of analytical techniques like mass spectrometry, which can detect and quantify trace amounts of the compound in complex biological matrices. MNPP-D8 is known to be a potent carcinogen, inducing tumors in multiple organs in animal studies. It is classified as a Group 2A carcinogen by the International Agency for Research on Cancer (IARC), indicating that it is probably carcinogenic to humans. The mechanism of carcinogenicity is thought to involve the formation of DNA adducts, which can lead to mutations and chromosomal damage. Due to its carcinogenicity, the use of MNPP-D8 is highly regulated and restricted. It is not intended for human consumption or use in any form of therapy. Proper handling and disposal procedures must be followed to prevent exposure to the compound, which can be harmful to human health. If you are working with MNPP-D8, it is important to follow all safety protocols and regulations to minimize the risk of exposure and protect yourself and others.