1-Methyl-4-phenyl-4-piperidinol-d5

1-Methyl-4-phenyl-4-piperidinol-d5 is a deuterated derivative of 1-Methyl-4-phenyl-4-piperidinol, an analog of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). It is commonly used as an internal standard in research studies involving MPTP and its metabolites. 1-Methyl-4-phenyl-4-piperidinol-d5 is a clear, colorless liquid that is soluble in water and most polar organic solvents. It has a molecular formula of C12H16D5NO and a molecular weight of 202.34 g/mol. The deuterium substitution in the compound increases its stability and allows for more accurate quantification in analytical methods such as mass spectrometry. MPTP and its analogs like 1-Methyl-4-phenyl-4-piperidinol-d5 have been extensively studied for their ability to selectively damage dopaminergic neurons in the brain, leading to motor dysfunction and symptoms similar to Parkinson's disease. This makes them useful tools for investigating the mechanisms of neurodegeneration and developing potential treatments for Parkinson's disease. In conclusion, 1-Methyl-4-phenyl-4-piperidinol-d5 is a valuable chemical tool for researchers studying MPTP and its effects on the brain. Its deuterium substitution increases its stability and accuracy in analytical methods, making it a reliable internal standard in research studies.