2,4-diamino-6-hydroxy-5-isonitroso-pyrimidin

2,4-diamino-6-hydroxy-5-isonitroso-pyrimidin, also known as Dihydroorotic acid or DHODA, is a chemical compound that plays a crucial role in the biosynthesis of pyrimidine nucleotides. Pyrimidine nucleotides are essential components of DNA and RNA, which are responsible for genetic information and protein synthesis in living organisms. DHODA is involved in the conversion of orotic acid to uridine monophosphate, which is a precursor for the synthesis of pyrimidine nucleotides. DHODA is commonly used in biochemical research to study the enzymatic activity and regulation of pyrimidine biosynthesis. It is also used in drug discovery for the development of antiproliferative agents that target the pyrimidine biosynthesis pathway. DHODA inhibitors have been identified as potential therapeutic agents for the treatment of cancer, viral infections, and autoimmune diseases. The chemical structure of DHODA consists of a pyrimidine ring with two amino groups, a hydroxyl group, and an isonitroso group attached to it. DHODA is a highly reactive compound due to the presence of the isonitroso group, which can undergo various chemical reactions such as nitrosation, oxidation, and reduction. The chemical properties of DHODA make it a versatile compound for the development of new drugs and biocatalysts. However, the toxicity and stability of DHODA need to be carefully evaluated for its safe use in various applications.