Alternate Names Adenosine Stable Isotopes, Stable Isotopes of Adenosine
CAT No. CS-R-00219
CAS No. 653-63-4 (Unlabeled)
Category Stable Isotopes
Stock Enquire
Mol. Wt. Not Available
Mol. For. Not Available
Hazardous This is not a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Adenosine
Smileys [15NH2]C1=C([15N]=C[15N]2[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)C3)C2=[15N]C=[15N]1
Canonical Smiles C1C(C(OC1N2C=NC3=C(N=CN=C32)N)COP(=O)(O)O)O
Inchl InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1
IUPAC [(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
Controlled No
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2-Deoxyadenosine 5-monophosphate 15N5 (dAMP-15N5) is a nucleotide analog that is used for research purposes. It is a labeled form of dAMP, where the nitrogen atom in the purine ring is replaced with a stable isotope of nitrogen (15N). This substitution allows for the precise measurement of the metabolic turnover and fluxes of dAMP in vivo. dAMP-15N5 is commonly used in stable isotope tracing experiments to study nucleotide metabolism. It is administered to cells or organisms and the labeled atoms are incorporated into newly synthesized nucleotides. By measuring the isotopic enrichment of downstream metabolites, researchers can gain insight into the biosynthesis and breakdown of nucleotides in different tissues and under different conditions. In addition to its research applications, dAMP-15N5 can also be used in diagnostic assays for certain genetic disorders. Specifically, it can be used to measure the activity of the enzyme adenosine deaminase (ADA), which is involved in purine metabolism. Deficiencies in ADA activity can lead to severe combined immunodeficiency (SCID), a rare and life-threatening disorder. By measuring the levels of labeled dAMP in blood samples, ADA activity can be quantified and used as a diagnostic tool for SCID. Overall, dAMP-15N5 is a valuable tool for studying nucleotide metabolism and for diagnosis of certain genetic disorders. Its precise labeling and incorporation into nucleotides makes it a powerful tool for understanding cellular processes and disease mechanisms.

Related Compounds

Adenosine-13C5 cyclic monophosphate sodium salt | Adenosine-3' 13C | Adenosine-2-d1 | Adenosine-1' 13C | Adenosine 15N N1-Oxide | Adenosine-3’,5’-cyclic-13C5 Monophosphate | N6-(N-Threonylcarbonyl)adenosine-13C4,15N | Adenosine-13C10 15N5 | Adenosine-5' 13C | N6-Methyladenosine-d3 | Adenosine-2' 13C | Adenosine 13C5 | Adenosine 15N | Adenosine 5'-Monophosphate 13C5 |

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