4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-β-D-Glucuronide
| Product Name | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-β-D-Glucuronide |
|---|---|
| CAT No. | CS-T-58504 |
| CAS No. | 350508-29-1 |
| Category | Glucuronides |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Canonical Smiles | CN(CCCC(C1=C[N+](=CC=C1)C2C(C(C(C(O2)C(=O)[O-])O)O)O)O)N=O |
| InchIKey | VSVYJUYJFLYYSI-ZIZCHBSTSA-N |
| Inchl | InChI=1S/C16H23N3O8/c1-18(17-26)6-3-5-10(20)9-4-2-7-19(8-9)15-13(23)11(21)12(22)14(27-15)16(24)25/h2,4,7-8,10-15,20-23H,3,5-6H2,1H3/t10?,11-,12-,13-,14?,15+/m0/s1 |
| IUPAC | (3S,4S,5S,6R)-3,4,5-trihydroxy-6-[3-[1-hydroxy-4-[methyl(nitroso)amino]butyl]pyridin-1-ium-1-yl]oxane-2-carboxylate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-β-D-Glucuronide or NNAL-Gluc is a metabolite of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). NNAL is a potent carcinogenic compound found in tobacco smoke and is known to contribute to the development of different types of cancer, including lung, pancreatic, and liver cancer.
NNAL-Gluc is formed in the liver as a result of NNAL metabolism and is excreted from the body through urine. NNAL-Gluc is a glucuronide conjugate, which means it is a compound formed by the attachment of glucuronic acid to the NNAL molecule. This conjugation reaction is carried out by the enzyme glucuronosyltransferase, which is present in the liver.
NNAL-Gluc is an important biomarker for tobacco smoke exposure and is used in different studies to assess the extent of tobacco smoke exposure in different populations. NNAL-Gluc has been found to be a reliable marker for assessing the risk of lung cancer in smokers and non-smokers exposed to secondhand smoke.
In conclusion, NNAL-Gluc is a metabolite of the carcinogenic compound NNAL found in tobacco smoke. It is an important biomarker for assessing tobacco smoke exposure and the risk of developing different types of cancer.
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