4-[N-(Methyl-d3)-N-nitrosamino]-4-(3-pyridyl)butane-1-ol

4-[N-(Methyl-d3)-N-nitrosamino]-4-(3-pyridyl)butane-1-ol is a chemical compound commonly used in biological and medical research. The compound is a labeled derivative of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine that is known to be a potent carcinogen. The labeled compound is used in various experiments to study the metabolism, distribution, and pharmacokinetics of NNK in vivo. In terms of chemical properties, 4-[N-(Methyl-d3)-N-nitrosamino]-4-(3-pyridyl)butane-1-ol has a molecular weight of 246.3 g/mol. It is a white crystalline powder that is soluble in water, ethanol, and methanol. The compound has a melting point of 143-145°C and a boiling point of 412.5°C at 760 mmHg. The compound is typically administered to laboratory animals via injection or gavage, and its distribution and metabolism can be monitored using various analytical techniques, including gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). The labeled compound is also used in studies to investigate the potential mechanisms of NNK-induced carcinogenesis and to develop new strategies for cancer prevention and treatment. In conclusion, 4-[N-(Methyl-d3)-N-nitrosamino]-4-(3-pyridyl)butane-1-ol is a valuable tool for researchers studying the biology and pharmacology of NNK. Its usage and chemical information provide valuable insight into the mechanisms of tobacco-induced carcinogenesis and the development of new cancer therapies.