5-Acetylamino-6-formylamino-3-methyl-d3-uracil

5-Acetylamino-6-formylamino-3-methyl-d3-uracil, also known as AMFU, is a synthetic nucleoside analogue that has been extensively studied for its use in cancer treatment. This compound is known to exhibit antitumor properties by inhibiting the growth of cancer cells and inducing apoptosis, or programmed cell death. It does so by incorporating itself into the replicating DNA of cancer cells, ultimately leading to the disruption of their cell cycle and ultimately their death. AMFU is also used as an intermediate in the synthesis of other nucleoside analogues such as the antiviral drug zidovudine and the anticancer drug capecitabine. Its chemical structure is similar to that of uracil, a naturally occurring nucleic acid base, but with the addition of an acetyl group and a formyl group. The chemical formula for AMFU is C10H11N3O5D3, and its molecular weight is 269.25 g/mol. The compound has a melting point of 235-238°C and is soluble in water and most organic solvents. AMFU is typically synthesized through a multistep process involving the condensation of various chemical reagents. In conclusion, AMFU is a valuable compound that has shown promise in cancer treatment and the synthesis of other important nucleoside analogues. Its unique chemical structure and properties make it a useful tool for researchers and pharmaceutical companies alike.