5-Amino-4-nitroso-2-(2-propoxyphenyl)pyrimidin-4(3H)-one

5-Amino-4-nitroso-2-(2-propoxyphenyl)pyrimidin-4(3H)-one is a chemical compound that belongs to the class of pyrimidine derivatives. It is a yellow crystalline solid with a molecular formula of C15H16N4O3. This compound is primarily used in the field of medicinal chemistry as a potent inhibitor of certain enzymes involved in the biosynthesis of purine nucleotides. The chemical structure of 5-Amino-4-nitroso-2-(2-propoxyphenyl)pyrimidin-4(3H)-one is characterized by the presence of an amino group, a nitroso group, and a propoxyphenyl group attached to the pyrimidine ring. The compound can be synthesized through a multistep reaction that involves the condensation of 2-aminopyrimidine with 2-propoxyphenylacetic acid, followed by nitrosation and reduction. In terms of its pharmacological properties, 5-Amino-4-nitroso-2-(2-propoxyphenyl)pyrimidin-4(3H)-one has been shown to exhibit potent inhibitory activity against inosine monophosphate dehydrogenase (IMPDH), an enzyme that plays a crucial role in the de novo synthesis of guanine nucleotides. This makes it a promising candidate for the development of new therapeutic agents for the treatment of various diseases, including cancer, autoimmune disorders, and viral infections. Overall, 5-Amino-4-nitroso-2-(2-propoxyphenyl)pyrimidin-4(3H)-one is a highly versatile compound with a wide range of potential applications in the field of medicinal chemistry. Its unique chemical properties and pharmacological activities make it an important target for further research and development.