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Harmine D3 is a deuterated form of harmine, a natural beta-carboline alkaloid found in a variety of plants including Banisteriopsis caapi and Peganum harmala. It is a psychoactive compound that has been traditionally used in shamanic rituals and spiritual practices in South America and the Middle East.
Harmine D3 is commonly used in neuroscience research as a selective inhibitor of the enzyme monoamine oxidase A (MAO-A), which is responsible for the metabolism of neurotransmitters such as serotonin, dopamine, and norepinephrine. By inhibiting MAO-A, harmine D3 increases the levels of these neurotransmitters in the brain, leading to mood enhancement, cognitive improvement, and neuroprotection.
Additionally, harmine D3 has been shown to have anticancer properties, as it can induce apoptosis and inhibit cell proliferation in various cancer cell lines. It also has anti-inflammatory and antioxidant effects, which may contribute to its neuroprotective properties.
Chemically, harmine D3 is a tricyclic indole alkaloid with a molecular formula of C13H10D3N3O. It has a melting point of 256-259°C and a boiling point of 393°C. Its structure consists of three rings, including a pyridine ring, a benzene ring, and an indole ring. Harmine D3 is slightly soluble in water and more soluble in organic solvents such as methanol, ethanol, and chloroform.
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