Paricalcitol Impurity 1 ( 22-Z-Paricalcitol )

Paricalcitol Impurity 1, also known as 22-Z-Paricalcitol, is a synthetic impurity of the drug Paricalcitol. Paricalcitol is a type of vitamin D analog that is used to treat secondary hyperparathyroidism in patients with chronic kidney disease. The drug works by regulating the levels of parathyroid hormone in the body, which can become imbalanced in patients with kidney disease. Paricalcitol Impurity 1 is a byproduct of the synthesis of Paricalcitol and is present in small quantities in the final drug product. It is important to monitor the levels of impurities in Paricalcitol as they can affect the safety and efficacy of the drug. The chemical structure of 22-Z-Paricalcitol is similar to Paricalcitol, but with a different arrangement of atoms in one part of the molecule. While Paricalcitol Impurity 1 has no known therapeutic activity, it is still important to understand its chemical properties and potential effects. The compound has a molecular weight of 416.67 g/mol and a melting point of 180-185°C. It is soluble in organic solvents such as methanol, ethanol, and chloroform, but insoluble in water. In conclusion, Paricalcitol Impurity 1 is a synthetic impurity of the drug Paricalcitol, which is used to treat secondary hyperparathyroidism in patients with chronic kidney disease. It is important to monitor impurities in Paricalcitol to ensure its safety and efficacy. While Paricalcitol Impurity 1 has no known therapeutic activity, its chemical properties and potential effects are still important to understand.